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REVIEW

Microbial remodeling of bile acids: emerging engineering strategies for precision fermentation and functional food innovation.

A review examines microbial bile acid conversion as a way to control metabolites linking diet and gut microbes with human metabolism and immunity. It surveys synthetic biology methods that rebuild bile acid pathways as modules in manageable microbial hosts. It also covers process optimisation, computational design, biosensors and encapsulation for improving scale and predictability. Such control could support pharmabiotics, functional foods and personalised microbiome treatments, but the abstract reports no performance data for these applications.

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Precision-fermented milk proteins as a model for industrial food biotechnology.

An opinion article assesses precision-fermented milk proteins as alternatives to livestock-linked dairy supplies, with implications for food, clinical products and infant nutrition. It compares β-lactoglobulin, α-lactalbumin and caseins by nutritional role, food function, production difficulty and market readiness. The authors report that better microbial hosts, protein secretion and process design have brought production closer to industrial use. They conclude that scale, accurate post-translational processing and careful protein selection matter more than expressing the correct genetic sequence alone.

Science digest

Emerging applications of Kluyveromyces marxianus in precision fermentation.

Kluyveromyces marxianus could support precision fermentation across several product classes, widening the choice of production organisms and feedstocks. The review examines work on bioethanol, organic acids, flavour compounds and enzymes. It considers strain screening, fermentation design, temperature, pH and oxygen supply. The authors link the yeast’s fast growth, tolerance of heat and acidity, varied substrate use and genetic diversity with its production potential. Better engineering tools help, but strain choice and process control remain decisive.

Science digest

High-pressure homogenization improves mycoprotein digestibility under an elderly static in vitro digestion model by disrupting cell-wall-related structural barriers.

High-pressure homogenisation broke down mycoprotein structures and improved digestion under simulated older-adult conditions, which could aid the design of high-protein foods for ageing populations. Researchers compared untreated and treated mycoprotein with pork and commercial plant-based meat in a static oral, gastric and intestinal model. Treatment left major nutrient composition largely unchanged, cut mean particle size by more than 80% during digestion and increased hydrolysis. Free amino acid release neared pork levels and exceeded the untreated and plant products. The case for older-adult foods is credible, but remains laboratory-based.