Viral Infectious Diseases and Gene Expression in Insects
Porcine PK15 kidney epithelial cells adapted better through staged serum reduction than direct reduction, offering a possible route to scalable seed cell growth for cultivated meat. Researchers compared both methods, moved low-serum adherent cells into serum-free suspension, returned them to adherent culture, and analysed gene expression. Sequential adaptation preserved proliferation, cell-cycle progression and epithelial traits, while suspension cells shifted towards more efficient energy use. Re-adherence partly restored morphology, growth features and oxidative-stress measures. Reversible genes centred on adhesion and metabolism, making staged adaptation the stronger method tested.
27 September 2026
Enzyme-mediated dye degradation
Fusarium venenatum A3/5 used waste-relevant carbon sources in markedly different ways, affecting feedstock choices for mycoprotein production. Researchers combined microlitre cultures, optical-density calibration, UHPLC time series and Gompertz models. Glucose and sucrose enabled fast growth but produced low biomass yields and substantial ethanol. Fructose gave the highest yield, at 0.49 g/g, while lactose consumption reached only 34% after 234.5 hours. An expired functional drink produced 18.37 g/L biomass, versus 12.49 g/L for a matched synthetic control. Beverage waste was the strongest tested feedstock, but evidence covers one real waste stream.
27 September 2026
Science digest
A review maps how milk proteins from humans, cows, goats and camels could be chosen and made through precision fermentation, addressing design gaps in target selection and protein processing. It compares sequences, structures and post-production modifications, then assesses host engineering, scale-up, purification and AI methods. Human proteins suit infant nutrition and immune uses, while ruminant proteins fit current expression systems better. α-Lactalbumin and β-lactoglobulin need fewer modifications than caseins and lactoferrin. AI cannot yet optimise yield, folding and modification accuracy together, leaving scale-up, glycoengineering and regulation unresolved.
27 September 2026